Healthy
Conditions
Keywords
Healthy, normal menstrual cycles
Brief summary
This study will recruit 50 healthy women with normal menstrual cycles aged 40-50, to investigate the expression of their NEI network and urine metabolomics.
Interventions
None listed
Sponsors
Wuxi People's Hospital
Shanghai University of Traditional Chinese Medicine
Study design
Observational model
CASE_CONTROL
Eligibility
Sex/Gender
FEMALE
Age
40 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
1. Healthy women with normal menstrual cycles aged 40-50. 2. The score of Kupperman index is less than 15. 3. Not alcoholics or smokers (past or smoking). 4. Get subjects informed consent process should comply with GCP requirements.
Exclusion criteria
1. Volunteers with heart, liver, kidney disease or acute or chronic gastrointestinal diseases, or with diseases of blood, endocrine, neurological and other systems. 2. Volunteers are participating in other clinical trials within 3 months. 3. Volunteers who donated blood or loosed blood heavily within 3 months. 4. Volunteers with previous history of mental illness, drug abuse or drug dependence. 5. Volunteers who took drugs within 14 days before the trail.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The expression of NEI network and Urine metabolomics | 2-5 days after menstruation | The indices of NEI network include: 1. Hypothalamic-pituitary-adrenal axis: CRH, ATCH, CORT 2. Hypothalamic-pituitary-thyroid axis: TRH, T3, T4 3. Renin - angiotensin - aldosterone system: PRA, Ang2, ALD 4. Sex hormones: E2, FSH 5. Immune factors: TNF-α、IL-6、IL-1 6. Cardiovascular indicators: ET, NO, Hcy, Folic acid |
Countries
China
Contacts
Primary ContactZheng Qingshan, PhD
Outcome results
None listed