Acute Renal Injury
Conditions
Brief summary
we hypothized dexmedetomidine could reduce the reduction of renal function after cardiopulmonary bypass weaning in pediatric patients
Detailed description
dexmedetomidine, a2-adrenoreceptor agonist has been used for sedation or hemodynamic stability for operative procedure. It had been already reported that dexmedetomidine reduce the impairment of renal functon after cardiac operation in adult. we hypothized dexmedetomidine could reduce the reduction of renal function after cardiopulmonary bypass weaning in pediatric patients
Interventions
DRUGDexmedetomidine
administration of dexmedetomidine on dexemedetomidine group
DRUGno dexmedetomidine
no administration of dexmedetomidine on control group
Sponsors
Gachon University Gil Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Caregiver, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
1 Years to 6 Years
Healthy volunteers
No
Inclusion criteria
* 1-6yr pediatric cardiac patients
Exclusion criteria
* previous renal dysfunction
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| renal function | from anesthetic induction up to postoperative 2h | at immediate after anesthetic induction (baseline), after weaning of cardiopulmonary bypass, 2h after end of operationCPB, sodium and creatinine in the urine and serum, N-acetyl-b-glucosaminidase (NAG)and albumin in only urine could be studied |
Countries
South Korea
Outcome results
None listed