Hypoxic Encephalopathy
Conditions
Keywords
hypoxic encephalopathy, cardiac arrest, outcome, pupillary reflex
Brief summary
The trial will evaluate the use of the Neurological Pupil index NPi, measured with the digital pupillometer (NeurOptics) compared to clinical examination for better reliability. The investigators hypothesize that digital evaluation will offer a higher sensitivity/ specificity compared to clinical examination.
Detailed description
Absent pupillary reaction after cardiac arrest might indicate a severe hypoxic encephalopathy. Because the examination of the pupillary reaction is easy it is part of the clinical routine but due to the different medication and the dynamic process of reperfusion injury to the brain a clinical evaluation might be not precise enough. The NPi has been shown to be superior to clinical evaluation in different settings but without regard towards cardiac arrest survivors. The Pupillometer is a hand-held, cordless, and simple to use device which removes subjectivity in the measurement of pupil size and the pupillary light reflex.
Interventions
None listed
Sponsors
Charite University, Berlin, Germany
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* all survivors after cardiac arrest
Exclusion criteria
* underlying disease limiting the pupillary reflex
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Neurological Pupil index (NPi) on a scale from 0-5 | up to 7 days | NPi values by the device on a scale by 0-5; \>3 indicates normal reaction; \<3 abnormal. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Cerebral performance category (CPC) | Patients will be followed for the duration of hospital stay, an expected average of 2 weeks | cerebral performance category; 1-2 good outcome; 3-5 poor outcome |
Countries
Germany
Outcome results
None listed