Identification Sepsis Related Single Nucleotide Polymorphism (SNP) by Whole Exome Sequencing

Identification Sepsis Related SNP by Whole Exome Sequencing: a Prospective Observational Study

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01920217

Enrollment

1000

Registered

2013-08-09

Start date

2013-01-31

Completion date

2015-12-31

Last updated

2013-08-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sepsis

Keywords

sepsis, SNP, mortality

Brief summary

Sepsis is a common cause of death in intensive care unit, timely and accurate diagnosis and treatment directly affect the survival rate. Single nucleotide polymorphism (SNP) was promising genetic biomarker for sepsis patients. The present study was designed to screen several SNP by whole exome sequencing which evaluate the sepsis related snp site in order to be a new target for the treatment of sepsis.

Detailed description

The study is a non-intervention, prospective observational study. Purpose of this sudy is to screening several SNPs by whole exome sequencing which can be used as genetic marker for sepsis patients. We will collect whole blood samples from patients with sepsis inRespiratory Intensive Care Unit (RICU), the Emergency Intensive Care Unit (EICU), or the Department of Surgery's ICU 301 Hospital since January 2013, and then whole exome sequencing was used to Screen SNPs which were related to sepsis. Then another 500 sepsis patients and 500 normal controls were used to validated the sequencing results.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Yes

Inclusion criteria

* Clinical diagnosis of sepsis * Patients who agree with the study

Exclusion criteria

* Aged \<18 years; * Into the group who died within 24 hours; * Agranulocytosis (\<0.5 × 109 / L); * Combined HIV infection.

Design outcomes

Primary

Measure	Time frame
sepsis related SNP site	28 days after admitted to ICU

Countries

China

Contacts

Primary ContactHuijuan Wang, Dr

wanghuijuan301@gmail.com+86 13466791738

Outcome results