Focus: Breast Cancer With Axillary Node Metastasis
Conditions
Brief summary
The study was performed to determine if either ultrasound guided core biopsy or fine needle aspiration of an axillary lymph node has superior sensitivity in detecting metastatic carcinoma from the ipsilateral breast.
Detailed description
Women with suspected or recently diagnosed breast cancer and ipsilateral abnormal appearing axillary lymph nodes underwent fine needle aspiration immediately followed by core biopsy of the same lymph node.Cytology results from the fine needle aspiration (FNA)and histology from the core biopsy were compared to surgical pathology from axillary node excision to determine if either method of percutaneous node sampling was more sensitive in detecting metastasis. Pain during each procedure was also compared.
Interventions
PROCEDUREFine needle aspiration and core biopsy of lymph node
Ultrasound guided fine needle aspiration of an abnormal lymph node followed by ultrasound guided core biopsy of the same node followed by clip placement into the node.
PROCEDUREAxillary surgery
Patients underwent axillary node dissection or excision of setinel axillary nodes at the time of surgical treatment of their breast cancer.
OTHERTitanium marker
A titanium marker was deposited into the lymph node that was percutaneously biopsied , immediately after the last tissue sample obtained.
Sponsors
Suros Surgical (now Hologic )
University of Pittsburgh
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Healthy volunteers
No
Inclusion criteria
* Women with breast cancer and abnormal ipsilateral axillary nodes visible on sonography.
Exclusion criteria
* Inability to understand consent form. * Emotionally unprepared to discuss possibility of axillary metastasis * Node not amenable to core biopsy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Fraction of metastatic nodes found at axillary surgery that were identified pre-surgically by FNA vs. core biopsy | 1 week to 10 months | Results of FNA cytology and core biopsy histology are compared to axillary surgery results. |
Other
| Measure | Time frame | Description |
|---|---|---|
| Pain associated with each type of percutaneous biopsy procedure | immediate at time of biopsy | Patients were asked to report pain level during the 2 types of percutaneous biopsy. |
Countries
United States
Outcome results
None listed