Epilepsy, Unspecified, Pharmacologically Resistant, Memory Impairment
Conditions
Keywords
epilepsy, surgery, functional MRI, memory outcome
Brief summary
This study has two purposes: firstly, a better understanding of the neurobiological processes underlying episodic memory and, secondly, the development of useful clinical applications for epileptic patients, in particular the prediction of postoperative memory deficits and the development of cognitive remediation therapies. Memory performances during a fMRI experiment will be assessed in controls and epileptic patients before and after the surgery.
Interventions
OTHERNo intervention
Sponsors
Institut National de la Santé Et de la Recherche Médicale, France
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Patients with drug-resistant epilepsy * Age of 18 years or more * Follow-up in the epilepsy unit at Pitié-Salpêtrière Hospital * Before or after the presurgical evaluation unit including a video-EEG monitoring, a structural brain imaging and a full neuropsychological assessment * Covered by a social security system * Signing of consent form
Exclusion criteria
* Persons under guardianship, curatorship or any other administrative or judicial deprivation of rights and freedom * Refusal to consent form * Contraindications to MRI * Pregnancy * Refusal to be informed in the case of detection of an abnormality during the experiment
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Measure of successfull encoding | 8 years | Our goal is to define correlation between the measure of successfull object encoding trials (especially for binding) and the beta value activation in fMRI |
Countries
France
Contacts
Primary ContactSophie DUPONT, MD, PhD
Backup ContactVirginie LAMBRECQ, MD
Outcome results
None listed