Bacteremia
Conditions
Keywords
Blood culture, Contamination, Chlorhexidine gluconate, Povidone iodine
Brief summary
To evaluate the efficacy of 2% chlorhexidine gluconate in 70% alcohol compared with 10% povidone iodine in reducing blood culture contamination in pediatric patients.
Detailed description
This is a prospective study of pediatric patients between 0-15 years of age who were admitted in three pediatric wards: general pediatric ward aged \<5 years, general pediatric ward aged \>5 years, and pediatric intensive care unit at a tertiary-care teaching hospital. Patients who needed percutaneous blood cultures were eligible for enrollment and were classified into two groups according to antiseptic used: 10% povidone iodine in odd months and 2% chlorhexidine gluconate in 70% alcohol in even months. Blood cultures were taken primarily by ward nurses using standard technique. The blood cultures were analysed and monitored for 5 days. Isolated organisms and their antimicrobial susceptibilities were determined using standard microbiologic techniques. Blood culture isolates were categorized into two groups including a true pathogen and a contaminant by clinical criteria combined with laboratory data. A blood culture was classified as contaminated if common skin flora such as Coagulase negative staphylococci, Corynebacterium spp., Micrococcus spp., or Bacillus spp. were isolated from one of the blood culture samples without isolation of the same organism from another potential infection site (for example, intravenous catheter), or a common skin flora was isolated in a patient with incompatible clinical features and improved without specific treatment for that organism.
Interventions
DRUG10%povidone iodine
skin preparation before venipuncture for blood culture in odd month
DRUG2% chlorhexidine gluconate in 70% alcohol
skin preparation before venipuncture for blood culture in even month
Sponsors
Thammasat University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
1 Days to 15 Years
Healthy volunteers
No
Inclusion criteria
* Pediatric patients between 0-15 years of age who were admitted in three pediatric wards: general pediatric ward aged \<5 years, general pediatric ward aged \>5 years, and pediatric intensive care unit. Patients who needed percutaneous blood cultures were eligible for enrollment.
Exclusion criteria
* Preterm infant * Patient who had skin infection at site of venepuncture * Patient who had history allergy to 2% Chlorhexidine gluconate in 70% alcohol or 10% povidone-iodine
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| efficacy of 2% chlorhexidine gluconate in 70% alcohol compared with 10% povidone iodine | 5 days | Pediatric patients who needed percutaneous blood cultures were recruited and were assigned 10% povidone iodine in odd months and 2% chlorhexidine gluconate in 70% alcohol in even months as an antiseptic for blood cultures. Blood culture isolates were categorized into two groups including a true pathogen and a contaminant by clinical criteria combined with laboratory data. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| safety of 2% chlorhexidine gluconate in 70% alcohol compared with 10% povidone iodine | 48 hours | direct observe skin reaction after use both antiseptics |
Countries
Thailand
Outcome results
None listed