Autism
Conditions
Brief summary
rTMS over dorsolateral prefrontal cortex is effective in reducing repetitive behaviors in adults with autistic spectrum disorder rTMS over posterior superior temporal sulcus is effective in improving social ability in adults with autistic spectrum disorder
Detailed description
First, we will apply one session intermittent theta burst stimulation over dorsolateral prefrontal cortex, posterior superior temporal sulcus and inion as control with one week interval in adults with autism spectrum disorder. Second, we will apply 5 sessions intermittent theta burst stimulation within one week over dorsolateral prefrontal cortex or posterior temporal sulcus depending on the results of our first phases.
Interventions
DEVICErepetitive TMS
rTMS (intermittent theta burst stimulation 1200)over posterior superior temporal sulcus,dorsolateral prefrontal cortex and inion as Sham control
Sponsors
Chang Gung Memorial Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
* adults with autistic spectrum disorder
Exclusion criteria
* schizophrenia * bipolar affective disorder * major depressive disorder * any systemic disease especially epilepsy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| continuous performance test | continuous performance test will be arranged before and after rTMS within one hour | continuous performance test will be arranged before and after rTMS within one hour |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Yale-Brown Obsessive Compulsive Scale | Yale-Brown Obsessive Compulsive Scale will be evaluated before and after rTMS within one week | Yale-Brown Obsessive Compulsive Scale will be evaluated before and after rTMS. The time point of evaluation is before rTMS, one hour after rTMS, 3 days after rTMS and one week after rTMS. |
Other
| Measure | Time frame | Description |
|---|---|---|
| Autism Spectrum Quotient | Autism Spectrum Quotient will be evaluated before and after rTMS within one week | Autism Spectrum Quotient will be evaluated before and after rTMS. The time point of evaluation is before rTMS, one hour after rTMS, 3 days after rTMS and one week after rTMS. |
Countries
Taiwan
Contacts
Primary ContactHsing Chang Ni, MD
Outcome results
None listed