Exploratory Behavior
Conditions
Brief summary
Our objective is to investigate neuro-anatomical correlates of the regulation of energy intake by means of functional MRI. Administration of glucose with and without lactisole and exendin as well as fructose is followed by functional brain MRI, and findings are correlated with serum GLP-1 levels as an endogenous satiety signal in humans.
Interventions
DIETARY_SUPPLEMENTtap water
DIETARY_SUPPLEMENTSingle intragastric instillation of 75g Glucose in 300ml tap water via nasogastric tube
DIETARY_SUPPLEMENTSingle intragastric instillation of 75g Glucose in 300ml tap water with 450ppm lactisole
DIETARY_SUPPLEMENT25g Fructose in 300ml tap water
DIETARY_SUPPLEMENT75g glucose in 300ml tap water with 600pmol/kg/min exendin 9-39
DIETARY_SUPPLEMENT300ml tap water with 450ppm lactisole
Sponsors
University Hospital, Basel, Switzerland
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
MALE
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
* right-handed healthy males, no drugs, non-smoking
Exclusion criteria
* drug abuse, smoker, left-handed, claustrophobia
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Functional magnetic resonance imaging (fMRI) in healthy volunteers while they performed a working memory task: changes in cerebral blood flow and blood hormones from baseline to treatment | changes from baseline to one hour after treatment | Whole brain analysis with a cluster-level threshold was followed by an a priori defined region of interest analysis of the dorsolateral prefrontal cortex including a cluster-level threshold and family-wise error adjustment for multiple comparisons. |
Countries
Switzerland
Outcome results
None listed