Adiposity, Body Composition, Childhood Obesity, Metabolic Risk Factors
Conditions
Brief summary
Children born to obese women are at risk of increased adiposity and later adverse metabolic outcomes. We have conducted a follow-up study on an existing clinical trial, called the LiP study (Lifestyle in Pregnancy), registration number NCT00530439,in which 360 obese pregnant women were randomized to either lifestyle intervention or routine obstetric care. This present study follows the children until 3 years of age. We have the hypothesis, that the intervention during pregnancy results in a lower degree of adiposity and metabolic risk factors in the offspring. Clinical examination is taking place at age 2.5-3 years including anthropometric measurements, Dual energy x-ray (DXA) scans and blood samples measuring metabolic markers.
Interventions
BEHAVIORALLifestyle intervention
Energy requirements for each participant were individually estimated according to weight and level of activity during pregnancy. Women in the active intervention group were encouraged to be moderately physically active 30-60 minutes a day.Women in this group also had free full time membership in a fitness center for six months. In the fitness centers they had closed training classes with trained physiotherapists for one hour each week.
Sponsors
Odense University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
30 Months to 40 Months
Healthy volunteers
Yes
Inclusion criteria
* children born to women who were part of the preceding LiP study and who completed the LiP study until birth. Inclusion criteria for the LiP study: * singleton pregnant * BMI \>/= 30 and \</= 45 E xclusion Criteria for preceding LiP study: * Chronic diseases * Not Danish speaking * Abuse of alcohol or drugs * Preterm delivery in earlier pregnancies
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Body Mass Index standard deviation score | On average 2.9 years of age |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Fat mass percent | On average 2.9 years of age | Fat mass estimated by dxa scans. |
Other
| Measure | Time frame | Description |
|---|---|---|
| Anthropometric and metabolic risk factors and bone mineralization | On average 2.9 years of age | BMI, Skinfold thicknesses, abdominal circumference, hip circumference, abdominal to hip circumference ratio, height, weight. DXA scan: fat mass, fat mass percent, lean mass, lean mass percent, body fat distribution. Bone mass density, bone mass content. Fasting blood glucose, HbA1C, fasting insulin, fasting c-peptide, fasting lipids; HDL; LDL, triglycerides, total cholesterol. 25-hydroxy vitamin D. Bone mineralization measured by dual energy x-ray |
Countries
Denmark
Outcome results
None listed