Klinefelter Syndrome
Conditions
Keywords
Klinefelter Syndrome, Azoospermia, Seminal analyses, Testicular biopsy
Brief summary
Klinefelter Syndrome (KS) is the most common sex chromosomal abnormalities (1/600 newborn males), and is characterized by a hypergonadism hypogonadism. Until few years ago, mostly non-mosaic KS was considered as a model of a complete male infertility although few KS (4-8%) have an oligospermia. Recent studies in adult with non-mosaic KS reported the possibility of sperm retrieval by testicular biopsy (TESE) in around 50% cases and more than some pregnancies have been obtained after TESE with Intracytoplasmic Sperm Injection (ICSI). Since 1997, more than one hundred births are described. As some studies shown a decrease of successful sperm retrieval with the increasing of age, we plan to compare the potential of sperm retrieval between two groups adult (23-55 years) and young after the onset of puberty (15-22 years). The study will be performed by searching spermatozoa on two seminal analyses spaced out 3 months followed by a testicular biopsy if the azoospermia is confirmed on semen analyses.
Interventions
PROCEDURESeminal analyses and testicular biopsy
Two seminal analyses spaced out 3 months followed by a testicular biopsy if the azoospermia is confirmed on semen analyses.
Sponsors
Hospices Civils de Lyon
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
15 Years to 55 Years
Healthy volunteers
No
Inclusion criteria
* Klinefelter Syndrome with 47,XXY non-mosaic * Androgenotherapy stopped since more than 6 months
Exclusion criteria
* Antecedent of Radiotherapy or chemotherapy * Psychological trouble * Treatment interfering with spermatogenesis * Androgenotherapy non stopped
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| TEsticular Sperm Extraction (TESE) | 15 months | Improvement of sperm retrieval rate by Testicular Sperm extraction (TESE) in the Young group compare to Adult group. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Prognosis factors | 15 months | Identification of prognosis factors of sperm retrieval (by TESE) in the two groups Young and Adult |
| Androgenotherapy | 15 months | Influence of antecedent of androgenotherapy before Testicular Sperm extraction (TESE) : treatment or not, duration of treatment |
| Histopathologist analyses | 15 months | Histopathologist analyses of testicular biopsy in the two groups Young and Adult. In the 2 groups, comparison of cases with and without sperm. |
Countries
France
Outcome results
None listed