Anti-oxidative Influence From Pomegranate Tablets on Male Sperm Quality in Couples Undergo Infertility Treatments Due to Male Infertility.

Status

UNKNOWN

Phases

Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01918163

Acronym

Pomegranate

Enrollment

Registered

2013-08-07

Start date

2013-09-30

Completion date

2014-09-30

Last updated

2013-08-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Male Infertility With Severe Oligo-terato-asteno-spermia

Keywords

pomegranate pills, male infertility, pregnancy rate, semen analysis, ROS, oxidative stress

Brief summary

Some animal studies revealed that the pomegranate juice may improve sperm quality in terms of concentration, motility and morphology, as well as in fertilization rate. Minor data is available regarding the influence on male sperm.

Detailed description

Pomegranate contains a high concentration of vitamins ( C, B1, B2, B3, B5), potassium, Magnesium , Zinc and is a good source for polyphenols .Polyphenols molecules have been found to possess antioxidant properties and may effects the expression of different genes . Recent studies indicate that among foods that contain polyphenols, juice extracted from the pomegranate has the highest concentration of measurable polyphenols . Pomegranates have shown inhibitory effect on NF-κB and the MAP kinases JNK and ERK, which are critical steps in the cascade of events leading to inflammatory response. The NF- κB pathway is activated in response to bacterial infection and initiates the inflammatory cascade, which may explain the protective effect of Pomegranates on bacterial infections.

Interventions

DIETARY_SUPPLEMENTPomegranate pills

Study design

Allocation

RANDOMIZED

Intervention model

FACTORIAL

Primary purpose

SUPPORTIVE_CARE

Masking

NONE

Eligibility

Sex/Gender

MALE

Age

20 Years to 60 Years

Healthy volunteers

Yes

Inclusion criteria

* TMC of less than 5 million spermatogonia in native sperm and morphology less than 4% by Kruger criteria.

Exclusion criteria

* sensitivity to Pomegranate

Design outcomes

Primary

Measure	Time frame
pregnancy	24 month

Secondary

Measure	Time frame	Description
ROS (reactive oxidative stress )and Interleukins level in semen fluid	12 weeks	The unit for measure the ROS are Micromolar epicatechin equivalent

Countries

Israel

Contacts

Primary ContactEinat Shalom-Paz, MD

einatshalompaz@gmail.com972544899155

Backup ContactEllenbogen Adrian, MD

ellenbogen@hy.health.gov.il973506246722

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026