Low-dose Spinal Morphine for Post-Thoracotomy Pain After Video-Assisted Thoracoscopic Surgery

Low-dose Spinal Morphine for Post-Thoracotomy Pain After Video-Assisted Thoracoscopic Surgery: A Prospective Randomized Double-Blind Controlled Trial

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01917448

Enrollment

Registered

2013-08-06

Start date

2014-02-28

Completion date

2016-01-31

Last updated

2016-04-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Video-assisted Thoracoscopic Surgery

Keywords

postoperative pain, spinal morphine, video-assisted thoracoscopic surgery

Brief summary

One-thirds of patients underwent video-assisted thorascopic surgery still have severe pain. Therefore we want to demonstrate weather 0.15 mg spinal morphine would reduce 24 hour postoperative requirement comparing to control group.

Interventions

DRUGMorphine

spinal morphine 0.15 mg

OTHERcontrol

Patient receive only local infiltration without spinal analgesia

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* ASA (American Society of Anesthesiologist) physical status I to III, * Undergoing elective video-assisted thoracoscopic surgery at Siriraj and Thammasart Hospitals * capable of using a patient-controlled analgesia (PCA) machine * understanding the numeric rating scale (NRS) score for pain assessment.

Exclusion criteria

* history of allergy to the study drugs * bleeding disorder * infection of the back * refusing spinal anesthesia * history of cerebrovascular disease * using postoperative ventilator support were excluded

Design outcomes

Primary

Measure	Time frame
Total post-operative morphine requirement.	48 hours

Secondary

Measure	Time frame
Pain after surgery	48 hour

Countries

Thailand

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026