Coronary Heart Disease
Conditions
Keywords
L-Citrulline malate,Coronary Heart Disease, Brachial Index
Brief summary
In this randomized clinical trial before and after study we will assess the effect of L-citrulline malate on brachial index in patients with coronary heart disease based on their smoking history. Twenty patients with coronary heart disease with no history of diabetes or other chronic diseases and with no history of myocardial infarction in the last 6 months will participate in our trial.A written well-versed permission was attained from all patients. We will measure the brachial index tow times once before giving L-Citrulline malate and the other time after 2 weeks giving it.Patients receiving L-Citrulline malate as a 1 gram dry powder agent twice a day, that should in use with 250 mg dilute water .The patients will followed after 2 weeks by measuring brachial index which is our primary outcome measurement in this trial.We assumed that the brachial index in both smoker and non-smoker group of patients with coronary heart disease would change to normal or close to normal after giving 1 gram L-citrulline malate twice a day for 2 weeks.
Interventions
L-Citrulline malate as a 1gr powder agent, twice a day, for 2 weeks and placebo as a 1gr powder agent of O.R.S, twice a day,for 2 weeks
Sponsors
Shahid Beheshti University of Medical Sciences
Masih Daneshvari Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
16 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
1- patients with coronary heart disease without history of diabetes or any chronic disease 2- no myocardial infarction in last 6 months 3-ejection fraction more than 50% 4- please to recruit in the trial 5-no uncontrolled blood pressure 6- with stable condition when come to the clinic
Exclusion criteria
1- those who refuse to being in the trial 2- those which their total condition become worse 3- CCU admission as a result of being unstable 4- patients with chronic heart failure(CHF)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Brachial Index | 2 weeks | Brachial Index according to the smoking history |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Brachial Index | 2 weeks | Brachial Index according to coronary heart disease |
Countries
Iran
Contacts
Primary ContactBabak Sharif-Kashani, cardiologist
Backup ContactParitash Tahmaseb-pour, M.D
Outcome results
None listed