Etomidate Overdose of Undetermined Intent
Conditions
Keywords
iv lidocaine, inducing dose, etomidate, dose response
Brief summary
IV lidocaine administration can reduce the minimal amount of Etomidate and time for induction of anesthesia.
Detailed description
The study was carried out in West China Hospital of Sichuan University, Chengdu, China. All the patients were informed in detail about the procedure and the medications they are going to get. Patients are well informed about the beneficial and possible hazards of the medicines and procedure. Patients are also informed that they can withdraw from the study at any time if they find it uncomfortable or harmful for them. Patients' written informed consent was obtained and registered for the permission from the Hospital's Ethics Board.
Interventions
DRUGLidocaine 1mg/kg
The total dosage of Etomidate needed for induction of anesthesia is recorded at last.
DRUGLidocaine 1.5mg/kg
same as other
DRUGLidocaine 2mg/kg
same as other
DRUGLidocaine 2.5mg/kg
same as other
Sponsors
West China Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
DOUBLE (Subject, Caregiver)
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
1. Patients scheduled for Elective Surgery, 2. age limit within 18-70 years, 3. American Society of Anaesthesiologists physical status classification I-II
Exclusion criteria
1. Adrenal Cortex disorder, 2. Neurologic disease, 3. Psychiatric disorders, 4. Allergic to Local anesthetic drugs, 5. Patients who have received sedatives,analgesics or opioids within the previous 24 hrs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| changes in blood pressure and heart rate. | 6 weeks |
Outcome results
None listed