Determining Optimal Post-Stroke Exercise (DOSE)

Conditions

Brain Diseases, Brain Infarction, Brain Ischemia, Central Nervous System Diseases, Cerebral Infarction, Cerebrovascular Accident, Cerebrovascular Disorders, Nervous System Diseases, Stroke, Vascular Diseases

Keywords

Exercise, Rehabilitation, Dose, Randomized controlled trial, Stroke

Brief summary

The investigators will conduct a proof-of-concept study to provide preliminary evidence of efficacy of physical exercise dose on ambulatory function in adults undergoing sub-acute stroke rehabilitation.

Detailed description

Participants admitted for stroke rehabilitation will be randomly assigned to either the Stroke Management Group, Stroke Monitoring Group or Stroke Supplementary Group. All three groups will receive usual care, in addition to the intervention. The Stroke Management Group will be provided with periodic information about their progress in the area of mobility using specialized activity monitors. The Stroke Monitoring Group will be progressed according to customized protocols using feedback from specialized activity monitors. The Stroke Supplementary Group will receive the same as the Stroke Monitoring Group, but will also receive one additional hour of daily (5 times per week) physical exercise

Ackerley S, Hung SH, Sheehy L, Donkers SJ, Timofeeva P, Best KL, Peters S, Park SS, Ouellet B, Ezeugwu VE, Milot MH, Sakakibara BM, Eng JJ, Connell LA.

2026-01-08

10.1186/s43058-025-00812-y

Higher intensity walking improves global cognition during inpatient rehabilitation: a secondary analysis of a randomized control trial

Sue Peters, Keith R. Lohse, Tara D. Klassen, Teresa Liu‐Ambrose, Sean P. Dukelow et al. (10 authors)

Frontiers in Neurology2023-06-091 citations

10.3389/fneur.2023.1023488

Step Number and Aerobic Minute Exercise Prescription and Progression in Stroke: A Roadmap

Sue Peters, Tara D. Klassen, Amy Schneeberg, Sean P. Dukelow, Mark Bayley et al. (9 authors)

Neurorehabilitation and neural repair2021-12-238 citations

10.1177/15459683211062894

Higher Doses Improve Walking Recovery During Stroke Inpatient Rehabilitation

Tara D. Klassen, Sean P. Dukelow, Mark Bayley, Oscar Benavente, Michael D. Hill et al. (12 authors)

Stroke2020-08-1997 citations

10.1161/strokeaha.120.029245

Consumer-Based Physical Activity Monitor as a Practical Way to Measure Walking Intensity During Inpatient Stroke Rehabilitation

Tara D. Klassen, Jennifer A. Semrau, Sean P. Dukelow, Mark Bayley, Michael D. Hill et al. (6 authors)

Stroke2017-08-0861 citations

10.1161/strokeaha.117.018175

Interventions

BEHAVIORALStroke Management Program (SMP)

Participants will have usual care, and in addition, be provided with periodic information about their progress in the area of mobility using specialized activity monitors

BEHAVIORALStroke Monitoring Program (SMonP)

Participants will have usual care, and in addition, be progressed according to customized protocols using feedback from specialized activity monitors

BEHAVIORALStroke Supplementary Program (SSP)

Participants will have usual care, and in addition, will receive the same as the Stroke Monitoring Group, and also receive one additional hour of daily (5 times per week) physical exercise

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

19 Years to No maximum

Healthy volunteers

No

Inclusion criteria

* Have been admitted to a hospital unit for stroke rehabilitation * Within 10 weeks post-stroke * 19 years or older * Are experiencing difficulty walking

Exclusion criteria

* Requires greater than one person assist for transfer or ambulation * Have uncontrolled medical condition or another serious medication condition in addition to stroke * Unable to understand or follow directions

Design outcomes

Primary

Measure	Time frame
Ambulatory function measured by the Six Minute Walk Test	Rehabilitation discharge (average 4-5 weeks post admission)

Secondary

Measure	Time frame
Ambulatory function from the 5 Meter Walk Test	Rehabilitation discharge (average 4-5 weeks post admission) , 6 and 12 months post-stroke
Balance function from the Berg Balance Scale	Rehabilitation discharge (average 4-5 weeks post admission), 6 and 12 months post-stroke
Ambulatory function from the Functional Ambulation Classification	Rehabilitation discharge (average 4-5 weeks post admission), 6 and 12 months post-stroke
Quality of life measured with EuroQol	Rehabilitation discharge (average 4-5 weeks post admission), 6 and 12 months post-stroke
Cognition measured by the Montreal Cognitive Assessment	Rehabilitation discharge (average 4-5 weeks post admission), 6 and 12 months post-stroke
Ambulatory Function from the Six Minute Walk Test	6 and 12 months post-stroke
Cognition measured by the Trail Making Test	Rehabilitation discharge (average 4-5 weeks post admission), 6 and 12 months post-stroke
Depression measured by Patient Health Questionnaire-9	Rehabilitation discharge (average 4-5 weeks post admission) , 6 and 12 months post-stroke
Heart rate measured during the intervention sessions	From 10 intervention sessions within the 4-week intervention
Step count measured during the intervention sessions	From 10 intervention sessions within the 4-week intervention
Cognition measured by the Digit Symbols Substitution Test	Rehabilitation discharge (average 4-5 weeks post admission) , 6 and 12 months post-stroke

Countries

Canada

Outcome results

None listed