Pharmacological Action (PA)
Conditions
Keywords
Ritalin, methylphenidate hydrochloride, experimental pain
Brief summary
1. To examine whether Ritalin has analgesic properties in healthy subjects. 2. To examine if Ritalin analgesic effect is a pain specific phenomenon or a part of a broader, non-specific effect on high mental functions.
Interventions
DRUGmethylphenidate hydrochloride
Sponsors
Rambam Health Care Campus
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
MALE
Age
20 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* Male subjects between the ages of 20 to 40 * Healthy subjects without known disease and without any chronic pain * Subjects without known cognitive problems, which can understand the research and its goals * Subjects who are not taking any medications * Subjects without hearing problems * Subjects without attention deficit disorder (ADHD) problems
Exclusion criteria
* Subjects who are known to suffer from any disease or any chronic pain * Subjects taking psychotropic drugs (except Ritalin) or any analgesics * Subjects who have any contradictions for ritalin administration * subjects with suspected cognitive disability
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Experimental pain intensity measured on a visual analogue scale (0-100) | 4 hours |
Secondary
| Measure | Time frame |
|---|---|
| effect of Ritalin on auditory sensitivity, measured by the response to different auditory stimulations | 4 hours |
| pain intensity (NPS 0-100) in response to thermal stimuli and the measures of the auditory tests. | 4 hours |
Countries
Israel
Outcome results
None listed