Hypertension, Prehypertension
Conditions
Keywords
Prehypertension, Hypertension, Sodium, Potassium, renin, aldosterone
Brief summary
Reduction in sodium consumption is important approach in public health care. In general population, reduction of sodium intake can reduce the future development of hypertension and cardiovascular event. Meanwhile, enhancement of potassium consumption is also important to reduce blood pressure and cardiovascular events. We hypothesized that combined education of low sodium and high potassium consumption is more effective in reducing blood pressure compared to dietary education of low sodium consumption only. The present survey study was designed to test the effectiveness of combined education of low sodium and high potassium consumption in blood pressure reduction and improvement of other variables.
Interventions
BEHAVIORALdietary education of low sodium and high potassium consumption
BEHAVIORALdietary education of low sodium consumption only
Sponsors
Ministry of Food and Drug Safety, Korea
DongGuk University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
20 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
1. Prehypertension: with a systolic pressure from 120 to 139 mm Hg or a diastolic pressure from 80 to 89 mm Hg 2. Stage 1 hypertension: with a systolic pressure from 140 to 159 mm Hg or a diastolic pressure from 90 to 99 mm Hg
Exclusion criteria
1. Urinary tract disease 2. Secondary hypertension 3. Previous history of unstable angina, heart failure, myocardial infarction, coronary revascularization, cerebrovascular disease within 12 months 4. Ventricular tachycardia, atrial fibrillation and flutter 5. Hypertrophic cardiomyopathy 6. Known chronic kidney disease: serum creatinine = or \> 2.0 mg/dL 7. Hypokalemia (\<3.5 mmol/L) or hyperkalemia (\>5.5 mmol/L) 8. Type 1 diabetes mellitus 9. Poorly controlled diabetes mellitus (HbA1C = or \> 9%) 10. Unable to collect 24 hour urine sample 11. Pregnancy 12. Alcoholics 13. Severe liver disease 14. Night workers 15. Mental retardation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| changes of 24-hour ambulatory systolic and diastolic blood pressure | 3 months | Effectiveness of combined dietary education of low sodium and high potassium consumption on changes of 24-hour ambulatory systolic and diastolic blood pressure, compared to dietary education of low sodium consumption only. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| changes of 24-hour urine sodium and potassium excretion | 3 months | Difference of changes of 24-hour urine sodium and potassium excretion by each dietary education |
| changes of renin and aldosterone | 3 months | Difference in changes of renin and aldosterone by each dietary education |
Other
| Measure | Time frame | Description |
|---|---|---|
| Changes of renin and aldosterone | 3 months | Changes of renin and aldosterone by low sodium consumption |
| Changes of pulse wave velocity | 3 months | Changes of pulse wave velocity by low sodium consumption |
| Changes of left ventricular mass index | 3 months | Changes of left ventricular mass index by low sodium consumption |
Countries
South Korea
Outcome results
None listed