Coagulopathy, Mesothelioma
Conditions
Brief summary
Surgery for malignant pleural mesothelioma is complex and prolonged, and may involve significant blood loss with considerable blood and product transfusion. Thromboelastography (TEG) is a global assay of coagulation that uses whole blood to produce a tracing that records kinetic changes in clot formation. This study aims provide a better understanding of the coagulation profile of these patients, and will form the basis of a TEG-based transfusion algorithm for future surgeries for mesothelioma.
Detailed description
Thromboelastography can provide more in-depth and quicker analysis of the complex coagulation processes during surgery
Interventions
PROCEDUREBlood draw for TEG analysis
Blood drawn for TEG analysis
Sponsors
Brigham and Women's Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Adult male or female patients undergoing elective surgery for malignant pleural mesothelioma
Exclusion criteria
* Unwilling or unable to provide consent * History of bleeding disorder * On medications that may affect hemostasis
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Coagulation profile during extrapleural pneumonectomy or pleurectomy | Surgical period (4-6 hours) | Reaction time, alpha angle, maximum amplitude and clot lysis from thromboelastography give a better picture of coagulation at different phases of surgery |
Countries
United States
Outcome results
None listed