Gestational Diabetes
Conditions
Keywords
omega-3 fatty acid, gestational diabetes, insulin sensitivity
Brief summary
This study is to examine the change of fasting insulin, glucose, insulin sensitivity and related traits in response to the 14 wk treatment of omega-3 fatty acids, including fish oil (n=25) and flaxseed oil(n=25), in Chinese gestational diabetic patients. Corn oil(n=25), rich in omega-6 fatty acids, will be selected as a controlled oil. The intervention will start from the third trimester of these pregnant women and finish at the 4wk after the birth of their children. The investigators hypothesize that omega-3 fatty acids could improve insulin sensitivity and glucose metabolism in these patients.
Interventions
DIETARY_SUPPLEMENTFish oil
DIETARY_SUPPLEMENTFlaxseed oil
Sponsors
National Natural Science Foundation of China
Zhejiang University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
* 1)gestational diabetes 2) female, \<40 years old 3)willing to participant in the trial
Exclusion criteria
* 1）type 1 diabetes or type 2 diabetes before pregnancy 2）Deny to sign the informed consent 3）Family history of hypertriglyceridemia or fasting triglyceride\>4.56 mmol/L 4）Have severe liver disease, kidney disease or cancer 5)Participating in the other clinical trial within 30 days 6)Other diseases or conditions, for which the doctor of the patients do not agree his or her participating
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| fasting glucose | 14 weeks |
| Fasting insulin | 14 weeks |
Secondary
| Measure | Time frame |
|---|---|
| birth weight, length of children | 10 weeks |
Other
| Measure | Time frame |
|---|---|
| blood lipids, inflammatory markers | 14 weeks |
Countries
China
Outcome results
None listed