Expected Duration of Ventilation > 48h, Intubation
Conditions
Keywords
endotracheal tube, ct scan, cleaning device, biofilm, mechanical ventilation
Brief summary
Cleaning the endotracheal tube with a specifically designed device results in lower amount of secretions at extubation, assessed by micro CT scan
Interventions
DEVICEstandard closed suctioning systems
Sponsors
Azienda Ospedaliera San Gerardo di Monza
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients admitted to an ICU * 18 years old or more * expected to be intubated for more than 48 hours * less than 24 hours from intubation * fraction of inspired oxygen set at the ventilator \<80%
Exclusion criteria
* Current or past participation in another intervention trial conflicting with the present study * expected survival less than 24 hours * Acute severe asthma * Use of Extracorporeal membrane oxygenation (ECMO) or candidates for ECMO * Double lumen endotracheal tube in place * Conditions which pose the patient at high risk if inadvertent endotracheal tube displacement occurs (laryngeal edema, cervical spine trauma, upper airways diseases with difficult reintubation) * other contraindications posed by staff physicians
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Volume of secretions | within 12 hours after extubation | Volume of secretions retained inside the endotracheal tube, assessed by micro ct scan |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| adverse events | until extubation, death or tracheostomy (approximately 2 weeks) | report of major and minor adverse events related to the use of the device |
Other
| Measure | Time frame | Description |
|---|---|---|
| endotracheal tube colonization | within 48 hours after extubation | assessed by microbiologic testing of the endotracheal tube lavage fluid |
Countries
Italy
Outcome results
None listed