Impact of Limb Remote Ischemic Preconditioning on Mortality and Quality of Life During Abdominal Aortic Aneurysm Repair

Impact of Limb Remote Ischemic Preconditioning on Mortality, Hospitalization Costs and Quality of Life During Elective Abdominal Aortic Aneurysm Repair: a Randomized Controlled Trial

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01910961

Enrollment

360

Registered

2013-07-30

Start date

2013-08-31

Completion date

2015-09-30

Last updated

2013-07-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Abdominal Aortic Aneurysm

Brief summary

To investigate the influence of limb remote ischemic preconditioning (LRIP) on mortality, hospitalization costs and quality of life in patients undergoing open infrarenal abdominal aortic aneurysm (AAA) repair.

Detailed description

Remote ischaemic preconditioning may confer the cytoprotection in critical organs. The investigators have revealed that limb remote ischemic preconditioning (RIPC) would reduce intestinal and pulmonary injury in patients undergoing open infrarenal abdominal aortic aneurysm (AAA) repair.Few groups have investigated the long term influence of limb remote ischemic preconditioning.Therefore, the investigators evaluated the impact of limb remote ischemic preconditioning on mortality, hospitalization costs and quality of life during elective abdominal aortic aneurysm repair in a prospective, randomized, controlled, single blind setting.

Interventions

PROCEDURElimb RIPC

LRIP consisted of three cycles of left upper limb ischemia induced by inflating a blood pressure cuff on the left upper arm to 200mmHg, with an intervening 5 minutes of reperfusion, during which time the cuff was deflated

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

* Clinical diagnosis of abdominal aortic aneurysm * Must be received open abdominal aortic aneurysm repair

Exclusion criteria

* age \>80 years old * Acute coronary syndrome or myocardial infraction within 3 months * Chronic obstructive pulmonary emphysema * angina pain within 48 hours of repair procedure * ejection fraction less than 40% * poor pulmonary function (PaO2 \<60mmHg)

Design outcomes

Primary

Measure	Time frame
all cause mortality	one year

Secondary

Measure	Time frame
hospitalization costs	30 days after operation

Contacts

Primary ContactCai Li, MD

licaigz@yahoo.com.cn+86-18602017796

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026