Normal Pressure Hydrocephalus
Conditions
Keywords
Normal pressure hydrocephalus, Flow MRI, Dementia, Cerebrospinal fluid, Shunt
Brief summary
Normal pressure hydrocephalus diagnosis based on quantitative study of cerebro-spinal fluid and blood flow by phase contrast magnetic resonance imaging.
Interventions
OTHERFlow imaging
Quantitative flow study was performed by 2D phase-contrast velocity-encoded cine MRI (repetition/echo time, 15/7 ms; field of view = 140 x 140 mm²; matrix size = 256 x 128, flip angle = 25 degrees,one excitation, slice thickness = 5 mm). Cerebrospinal fluid and blood flows are measured with a velocity-encoding value of 5-10 cm/s and 80 cm/s respectively. Peripheral gating was used to cover the entire cardiac cycle with retrospective cardiac synchronization of 32 quantitative flow-encoded images per cycle. Clinical examination consists in Larson's score and MMSE
Sponsors
Centre Hospitalier Universitaire, Amiens
Study design
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Ventricular dilation seen on morphological magnetic resonance imaging (MRI) * Walking disorder * Cognitive disorder * Participants gave their written informed consent
Exclusion criteria
* Contra-indication to MRI * Obstructive tumoral hydrocephalus * Curatorship or tutorship * Pregnancy or lactation * No social assurance
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| cerebrospinal fluid (CSF) stroke volume evolution other 6 months | Day 1 (baseline), Day 180 | Measurement of cerebrospinal fluid (CSF) stroke volume via flow MRI at the Sylvius' aqueduct, pontine cistern and spinal spaces levels and determination of its evolution |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Blood flow analysis : evolution other 6 months | Day 1 (baseline), Day 180 | Assessment of arterial (internal carotids and cerebral arteries) and venous (sagittal sinus, straight sinus) blood flow in terms of mean cerebral blood outflow and stroke volume and determination of blood flow evolution. |
| Larson's score evolution over 6 months | Day 1, Day 180 | Record symptoms on walking, living conditions and urinary disorders |
| Neuropsychological test evolution over 6 months | Day1, Day 180 | Consists in mini mental status evaluation (MMSE) for cognitive evaluation |
| Blood flow analysis : evolution other one year | Day 1 (baseline) and Day 365 | Assessment of arterial (internal carotids and cerebral arteries) and venous (sagittal sinus, straight sinus) blood flow in terms of mean cerebral blood outflow and stroke volume and determination of blood flow evolution. |
| Larson's score evolution over one year | Day 1 and Day 365 | Record symptoms on walking, living conditions and urinary disorders |
| Neuropsychological test evolution over one year | Day1, Day 365 | Consists in mini mental status evaluation (MMSE) for cognitive evaluation |
| cerebrospinal fluid (CSF) stroke volume evolution other one year | Day1 (baseline), Day 365 | Measurement of cerebrospinal fluid (CSF) stroke volume via flow MRI at the Sylvius' aqueduct, pontine cistern and spinal spaces levels and determination of its evolution |
Countries
France
Contacts
PRINCIPAL_INVESTIGATOROlivier Balédent, PhD
CHU Amiens
Outcome results
None listed