Acute Kidney Injury
Conditions
Keywords
AKI, atrovastatin, Valvular heart surgery
Brief summary
The aim of this study is to examine the association between preoperative statin treatment and the incidence of postoperative acute kidney injury(AKI) in patients undergoing valvular heart surgery.
Interventions
DRUGatrovastatin
Atrovastatin 80mg was administered orally on the evening before surgery. Before anesthesia induction, atrovastatin 40mg was administered orally. And atrovastatin 40mg were administered orally in the evening of postoperative days 0, 1, and 2.
DRUGPlacebo
Placebo 80mg was administered orally on the evening before surgery. Before anesthesia induction, placebo 40mg was administered orally. And placebo 40mg were administered orally in the evening of postoperative days 0, 1, and 2.
Sponsors
Yonsei University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
ALL
Age
20 Years to No maximum
Healthy volunteers
No
Inclusion criteria
\- patients over the age of 20 scheduled for valvular heart surgery
Exclusion criteria
1. Current statin use 2. Left ventricular ejection fraction \< 30% 3. Preexisting congestive heart failure 4. Severe coronary artery disease 5. Hemodynamically unstable arrhythmia 6. Cardiogenic shock during perioperative period 7. Ventricular assist device 8. Severe renal dysfunction (eGFR \< 15 ml/min per 1.73 m2) 9. History of liver disease or elevated serum transaminases 10. History of rhabdomyolysis or elevated creatinine kinase
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Comparison of postoperative renal function with or without statin in patients undergoing valvular heart surgery | renal function change from 24-hour after surgery to 120-hour after surery | BUN/Cr cystatin C eGFR urine output incidence of acute kidney injury(based on the AKIN criteria) |
Countries
South Korea
Outcome results
None listed