Pivotal Response Treatment for Children With Autism Spectrum Disorders

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01908686

Acronym

PRT

Enrollment

Registered

2013-07-26

Start date

2012-05-31

Completion date

2020-03-01

Last updated

2020-08-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Autism Spectrum Disorders

Keywords

ASD

Brief summary

The purpose of this study is to evaluate the application of an evidence-based, manualized treatment for children with Autism Spectrum Disorder (ASD) (Pivotal Response Treatment, PRT) to children ages four through six years of age with ASD. Specifically, children will be randomly assigned to receive either (1) 10 hours per week of intervention services, including two hours per week of parent education, and eight hours per week of direct clinician-delivered services, or (2) a treatment as usual control. Intervention will focus on enhancing the following developmental skills: expressive and receptive language, play, and social interaction. Outcome measures will address changes in the aforementioned domains during structured observation and standardized assessment.

Interventions

BEHAVIORALPivotal Response Training

Behavioral intervention for autism

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

TREATMENT

Masking

SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

4 Years to 35 Years

Healthy volunteers

Inclusion criteria

* Inclusion Criteria: Participants will: 1. Fit the age requirement: age 4-35 2. Have been diagnosed previously with an ASD and meet criteria for ASD when characterized by research team. 3. Be in good medical health 4. Be cooperative with testing 5. English is a language spoken in the family 6. Successfully complete an fMRI and EEG scan 7. Full-scale IQ\>50

Exclusion criteria

Design outcomes

Primary

Measure	Time frame
Social Responsiveness Scale (SRS) Total Score	16 weeks

Secondary

Measure	Time frame
Autism Diagnostic Observation Schedule (ADOS) Comparison Score	16 weeks
Aberrant Behavior Checklist (ABC)	16 weeks
Clinical Global Impressions Scale (CGI-I)	16 weeks
Change in Eye Tracking (ET) patterns	16 weeks
Change in neural response to social stimuli using fMRI	16 weeks
Vineland Domain Scores	16 weeks

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026