Exercise-induced Muscle Damage
Conditions
Keywords
Investigate IPC on EIMD
Brief summary
Strenuous exercise or exercise involving eccentric muscle contractions can lead to muscle damage and changes in muscle function; this is known as exercise-induced muscle damage (EIMD). It is known that brief, repeated periods of ischemia followed by reperfusion, known as Ischemic Preconditioning (IPC) cause a delay in cell injury in cardiac muscle as well as in various other organs. Therefore the purpose of this study is to: 1. Quantify the use of IPC in recovery following EIMD. 2. Identify any effect of IPC during recovery on muscle function
Interventions
OTHERIschemic Preconditioning
Sponsors
St Mary's University College
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
MALE
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* Physically Active Males
Exclusion criteria
* Muscular skeletal disorders
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change from baseline in maximal voluntary contraction | pre exercise, 24 hours post, 48 hours post and 72 hours post exercise | Isometric MVC of the participants' dominant knee extensors was assessed using a strain gauge. MVCs were performed for 3 s with a 60 s rest between each repetition. The change in MVC will be determined 24, 48 and 72 hours following pre exercise conditions. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change from baseline in Creatine kinase | pre exercise, 24 hours post, 48 hours post and 72 hours post exercise | Plasma CK was determined from an earlobe capillary blood sample. The sample (10 microlitres) was analysed immediately using an semi-automated clinical chemistry analyser. The change in CK will be determined 24, 48 and 72 hours following pre exercise conditions |
| Change from baseline in Limb girth | pre exercise, 24 hours post, 48 hours post and 72 hours post exercise | Mid-thigh and calf circumference was assessed as a measure of limb swelling using an anthropometric tape measure. Both measures were obtained with the participant in a standing position. The change in limb girth will be determined 24, 48 and 72 hours following pre exercise conditions |
| Chnage from baseline in Vertical jump | pre exercise, 24 hours post, 48 hours post and 72 hours post exercise | Vertical jump (VJ) performance was assessed using an electronic timing mat with hands placed on hips and participants dropping down to a self-selected level before jumping maximally. The change in VJ will be determined 24, 48 and 72 hours following pre exercise conditions |
| Change from baseline in Muscle soreness | pre exercise, 24 hours post, 48 hours post and 72 hours post exercise | Muscle soreness - Participants were asked to perform and hold a squat (90° knee angle) whilst they rated their perceived muscle soreness on a 200 mm visual analogue scale. The scale consisted of a line from 0 mm (no pain) to 200 mm (unbearably painful). The change in muscle soreness will be determined 24, 48 and 72 hours following pre exercise conditions |
Countries
United Kingdom
Outcome results
None listed