Patients With Anorexia Nervosa
Conditions
Keywords
Anorexia nervosa, Bone mineral density, Teenagers or young women, Bone remodelling markers
Brief summary
Nutritional deprivation of adolescent girls with anorexia nervosa (AN) reduces the bone mass acquisition. A better understanding of this process would improve the medical treatment of bone alteration and its long-term consequences. 160 patients (age \< 38 yr) with AN and 160 age-matched controls (CON) will be enrolled in this study. The areal bone mineral density (aBMD) will be determined using dual-X-ray absorptiometry. Calciotropic hormones, bone turnover markers will be concomitantly evaluated.
Interventions
OTHERclinical parameters description
description of weight, height, Bone Mass Index, dietary questionnary, amenorrhea time, pathology time for the two arms
OTHERpara clinical parameters description
description of DMO, mass, basal metabolism, IGF-1/IGFBP-3 for the two arms
OTHERhormonal parameters dosing
dosing of leptine, leptine receptor, adiponectine, ghreline for the two arms
OTHERbone modeling markers dosing
dosing of osteocalcine, bone alkalin phosphatase, C-telopeptide of type-I collagene, osteoprotegerine/ RANKL for the two arms
Sponsors
University Hospital, Montpellier
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
14 Years to 38 Years
Healthy volunteers
Yes
Inclusion criteria
* Informed Consent * Health Insurance regimen or benefit from an health insurance regimen * Aged from 14 to 38 years old * Women * No pregnant Specific inclusion criteria for patient: Patient suffering from anorexia nervosa defined by criteria of Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) Specific inclusion criteria for controls: * Normal menstrual cycles, * No lifetime history of eating disorders, * BMI between 18 and 25 kg/m²
Exclusion criteria
* use of treatments may be modify bone mass (bisphosphonates,…) * Disease or treatment may be induce osteoporosis * In exclusion period in relation with another study * Law protected subject
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Dual-X-ray absorptiometry (DEXA) | at Day 0 (time of the inclusion visit) | The primary outcome is to model the bone mass acquisition in young women with anorexia nervosa. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Biological parameters identification | At day 0 (time of the inclusion visit) | One of the secondary outcome is to identify biological factors associated with bone demineralisation. |
| clinical parameters identification | At Day 0 (at time of the the inclusion visit) | One of the secondary outcome is to identify the clinical factors associated with bone demineralisation. |
Countries
France
Contacts
PRINCIPAL_INVESTIGATORPatrick PL LEFEBVRE, MD
University Hospital, Montpellier
Outcome results
None listed