Coronary Artery Disease, Valvular Heart Disease
Conditions
Keywords
ischemia, reperfusion, myocardial ischemia, myocardial reperfusion
Brief summary
Strategies for myocardial protection during open heart surgeries are desired. Several experimental studies have shown beneficial effects of remote ischemic preconditioning (RIPC). The underlying mechanisms are not totally understood. This study intends to evaluate molecular mechanisms involved with RIPC on myocardium of patients underwent open heart surgeries.
Interventions
PROCEDUREIRPC, Remote preconditioning
The patients will be submitted to 5 minutes of upper limb compression by cuff followed by 5 minutes of reperfusion. This cycle will be repeated 4 times.
Sponsors
University of Campinas, Brazil
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Caregiver)
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Patients older than 18 years * Scheduled for coronary artery bypass grafting with or without valve replacement associated * Use of blood cardioplegia * EuroSCORE II greater than or equal to 1.0%
Exclusion criteria
* History of cardiogenic shock * Complications in the admission * Pregnant patients * Severe peripheral arterial disease affecting the upper limbs * Liver failure (bilirubin ˃ 20 mmol / L, INR 2.0 ˃) * Significant pulmonary disease (˂ FEV1 40%) * Renal failure with glomerular filtration rate ˂ ml/min/1,73 m² * Concomitant treatment with glibenclamide or nicorandil (medications that interfere with cardioprotection induced by IPCR)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Molecular pathway activation | 2 days |
| Inflammatory response | 10 days |
Secondary
| Measure | Time frame |
|---|---|
| All cause of mortality | 30 days |
Countries
Brazil
Contacts
Primary ContactOrlando Petrucci, MD, PhD
Outcome results
None listed