Adiposity, Weight Loss
Conditions
Brief summary
The broad aim of the study is to obtain a better understanding of alterations in mesolimbic reward pathways in adiposity based on the hypothesis of a hypofunctioning reward system in obesity. This will be achieved by integrating a functional neuroimaging (fMRI) with behavioral reward tasks and the modulation of the dopamine level by dopamine depletion.
Interventions
DIETARY_SUPPLEMENTDopamine depletion vs. Balanced aminoacid drink
Sponsors
University Hospital Tuebingen
Study design
Observational model
CASE_CROSSOVER
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
FEMALE
Age
21 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* female * healthy
Exclusion criteria
* fMRI contraindications * claustrophobia
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Differential brain functions in the dopaminergic reward system | 4 hours after intake of the dopamine depletion or balanced aminoacid drink | differential brain fuctions will be measured by blood oxygen level dependent effect. |
Secondary
| Measure | Time frame |
|---|---|
| amino acid level changes due to dopamine depletion | 4 hours after intake of the dopamine depletion or balanced aminoacid drink |
Countries
Germany
Outcome results
None listed