Gastric Cancer
Conditions
Keywords
Gastric caner, adjuvant chemotherapy
Brief summary
Adjuvant chemotherapy followed by curative gastrectomy for Stage II/III gastric cancer has improved disease free time and survival. However, there are still considerable number of patients experience relapse even after adjuvant chemotherapy. In an attempt to select patients who really benefit the postoperative adjuvant chemotherapy, we have identified potential biomarkers (NF-kappaB/JNK) from cell line panel screening followed by immunohistochemical validation. In the present study, we further validate the significance of the biomarkers in a larger set of clinical samples to see if chemotherapeutic response can be determined immediately after surgery.
Interventions
None listed
Sponsors
Iwate Medical University
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Pathologically confirmed gastric cancer. * Operated before November 2009. * Stage Ib/II(except for T1, T3N0)/III. * Received postoperative (R0) adjuvant chemotherapy (S-1). * Not received postoperative (R0) adjuvant chemotherapy (surgery alone). * Signed informed consent to provide paraffin embedded tissue of removed specimens.
Exclusion criteria
* With advanced neoplastic lesions other than gastric cancer. * Paraffin embedded tissue is not available. * Unknown S-1 treatment condition.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Relapse free survival | 3 years |
Countries
Japan
Outcome results
None listed