Microsurgical Free Flaps
Conditions
Keywords
Balanced anesthesia, Inhalation anesthesia, Reperfusion injury, Microsurgical Free flap
Brief summary
This study aimed to evaluate the possible protective effect of anesthetic technique balanced(with sevoflurane) compared with total intravenous anesthetic technique (propofol,remifentanil). The hypothesis is that the Sevoflurane may exert protective effect in regard to the ischemia-reperfusion injury induced on the microsurgical breast free flap during transfer to receiving area. The investigators will evaluate the continuous flap tissue oximetry and the level of biochemical markers.
Interventions
Et-Sevo maIntained 1,8-2%, remifentanyl according target-controlled infusion maintained 1-3 ng/ml
DRUGTotal intravenous anesthesia
Propofol 3-4 µg/ml and remifentanyl 1-3 ng/ml according target-controlled infusion
Sponsors
Regina Elena Cancer Institute
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
Patient selected for plastic breast surgery With microsurgical Free flap Over 18 y Asa I/II
Exclusion criteria
Unusual reaction to anesthetic drugs Suspect for malignant hyperthermia Vasculopathic disease Coagulation disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| continuous tissue oximetry (NIRS) | 20 hours |
Secondary
| Measure | Time frame |
|---|---|
| Biochemical Markers | Preoperative and 24 hours post operative |
| Lactate Clearance | 24 hours |
Countries
Italy
Outcome results
None listed