Regeneration Potential of Healthy Old Men in Terms of Satellite Cell Activation
Conditions
Brief summary
Randomised training intervention. Influence of consecutive training regime on the impact of the myonuclear domain and satellite cell Sarcopenia Despite that the muscle mass can be positively influenced by training, the loading with high weights and/or to the total exhaustion is for many old persons not possible. Therefore we aim to enhance the myonuclei in the muscle fiber of old male subjects in a first phase by endurance training, in order to promote a more effective muscle growth in a second phase by resistance exercise.
Interventions
PROCEDURETraining
Sponsors
University of Zurich
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
MALE
Age
18 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
-male * no fever at the beginning and during the study * between 60 years and 75 years * non smokers * no known cardiovascular and orthopaedic problems * no cardiac pacemaker * fulfilling the health criteria
Exclusion criteria
-female * fever or cold at the beginning or during the study * non MRI compatible metal implants * under 60 years or over 75 years * smoker * cardiovascular or orthopaedic problems * cardiac pacemaker * not fulfilling the health criteria
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Difference in % from baseline in fibre type specific number of satellite cells, fibre type specific myonuclear domain [um^2], myonuclear number [%] in response to consecutive training regimes | participants will be followed for the duration of training period, an expected average of 7 months | Difference in % from baseline in fibre type specific number of satellite cells, fibre type specific myonuclear domain \[um\^2\], myonuclear number \[%\] in response to consecutive training regimes |
Countries
Switzerland
Outcome results
None listed