Inflammation
Conditions
Keywords
exercise
Brief summary
Aerobic physical activity attenuates systemic inflammatory activity in individuals with cardiovascular risk.
Detailed description
Background: Observational studies suggest that exercise has anti-inflammatory effect, however this idea has not been definitively confirmed by randomized clinical trials. Objective: To test the hypothesis that aerobic exercise attenuates systemic inflammatory activity in individuals with cardiovascular risk. Methods: Randomized controlled trial, which included 68 sedentary individuals, with at least two risk factors for coronary heart disease or established cardiovascular disease. The volunteers were randomized to 3 months of supervised aerobic training or just advice when healthy lifestyles. C-reactive protein (CRP) was measured by the method of high sensitivity before and after 3 months of intervention.
Interventions
BEHAVIORALAerobic Exercise
BEHAVIORALOnly Counseling
Sponsors
Escola Bahiana de Medicina e Saude Publica
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
40 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
\- Individuals with are between 40 to 70 years, no regular exercise, and at least two risk factor for cardiovascular disease (diabetes, hypertension, dyslipidemia, smoking) or documented cardiovascular disease.
Exclusion criteria
\- Incapacity to exercise.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| C-reactive protein | 3 months |
Outcome results
None listed