Social Dysfunction and Brain Dysfunction in Patients With Schizophrenia

Resting-state Magnetic Resonance Imaging of Brain in Patients With Schizophrenia Compared With Healthy Controls to Prove the Association Between Social Cognition Dysfunction and Abnormality of Brain Function

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01903915

Enrollment

100

Registered

2013-07-19

Start date

2012-07-31

Completion date

2015-04-30

Last updated

2013-07-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Schizophrenia, Social Cognition

Brief summary

There were a few studies about the relationship of structural or functional abnormalities of brain and social cognitive dysfunctions in patients with schizophrenia. In addition, default network, which increases activity during mental explorations referenced to oneself including remembering, considering hypothetical social interactions, and thinking about one's own future, may be associated with social cognitive dysfunctions in patients with schizophrenia. Therefore, we will investigate the dysfunction of default network in patients with schizophrenia compared with healthy controls and the effect of default network dysfunctions on the social cognition in patients with schizophrenia.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

20 Years to 40 Years

Healthy volunteers

Yes

Inclusion criteria

Patients group inclusion criteria: * Right-handed * Intelligent Quotient(IQ) above 80 * can read and understand the informed consent * schizophrenia patients who was diagnosed from Structured Clinical Interview for Diagnostical and Statistical Manual of Mental Disorder 4th edition(DSM-IV, nonpatient version(SCID-NP) scales * patient who has had reality distortion symptoms (like delusion or hallucination) in 5 years Control group inclusion criteria : * Right-handed * IQ above 80 * do not have any diagnosis from SCID-NP scales * do not have any family members who have psychiatric disorder

Exclusion criteria

* have Illness which can affect brain structures and functions * can't be taken magnetic resonance imaging(MRI)

Design outcomes

Primary

Measure	Time frame	Description
Comparison of resting state functional MRI between schizophrenia patients and healthy controls	Baseline	After subjects are enrolled the study, functional MRI of the brain will be measured on rest. They will lie down in MRI machine and just open their eyes. There is no tasks for functional MRI. Unless the subject don't have any contraindication for MRI, they can be take MRI of brain safely. Resting-state functional brain MRI Data from subjects will be analysed statistically. We will use programs for image processing and statistical work, such as REST, Statistical Parametric Mapping(SPM), Freesurfer. For comparison between two groups, student t-test will be used.

Countries

South Korea

Contacts

Primary ContactJung-Sun Lee, MD

js_lee@amc.seoul.kr82 2 3010 3422

Outcome results