Fasciculations, Intubating Conditions, Patient Satisfaction, Postoperative Myalgia, Sore Throat
Conditions
Keywords
succinylcholine, rocuronium, sugammadex, Intubating Conditions, short Procedures
Brief summary
Succinylcholine is commonly used for neuromuscular relaxation for short procedures such as rigid bronchoscopy. A more modern alternative is the application of low-dose rocuronium, reversed by low-dose sugammadex. The investigators compare the intubating conditions, incidence of postoperative myalgia (POM), as well as patient satisfaction for these two muscle relaxants.
Interventions
DRUGSuccinylcholine
Anaesthesia was induced and maintained with propofol (1-2 mg/kg) and remifentanil (0.5 µg/kg). The study arm was immobilized and a dual electrode for peripheral nerve stimulation was placed over the ulnar nerve near the wrist. Neuromuscular monitoring was performed with accelerometry.The patients received succinycholine according to the study group.
DRUGRocuronium/Sugammadex
Anaesthesia was induced and maintained with propofol (1-2 mg/kg) and remifentanil (0.5 µg/kg). The study arm was immobilized and a dual electrode for peripheral nerve stimulation was placed over the ulnar nerve near the wrist. Neuromuscular monitoring was performed with accelerometry.The patients received rocuronium/sugammadex according to the study group.
DRUGRocuronium
Anaesthesia was induced and maintained with propofol (1-2 mg/kg) and remifentanil (0.5 µg/kg). The study arm was immobilized and a dual electrode for peripheral nerve stimulation was placed over the ulnar nerve near the wrist. Neuromuscular monitoring was performed with accelerometry.The patients received rocuronium according to the study group.
Sponsors
Dr. Horst Schmidt Klinik GmbH
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* age \> 18 yr * scheduled for elective rigid bronchoscopy
Exclusion criteria
* known neuromuscular disease * significant hepatic or renal dysfunction * family history of malignant hyperthermia * known allergy to one of the drugs used in this protocol * pregnancy or breastfeeding
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Intubating condition | After induction of general anaesthesia (after 3-5 minutes) | scoring system proposed for Good Clinical Research Practice using the following variables: conditions of inserting rigid bronchoscope, vocal cord position, and coughing |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Fasciculations | After application of the neuromuscular blocking agent (after 3-5 min) | Fasciculations were graded by the investigator on the following four-point scale 0 = no fasciculations 1. = mild, fine fasciculations of the eyes, neck, face or fingers, without limb movement 2. = moderate fasciculations occurring at more than two sites, or obvious limb movement 3. = vigorous or severe, sustained and widespread fasciculations in the trunk and limbs |
| Postoperative Myalgia (POM) | 72 Hours after Intervention | The severity of POM was measured using a four-point scale 0 = no myalgia 1. = minor pain limited to one area of the body 2. = muscle pain or stiffness noticed spontaneously by the patient, which may have required analgesic therapy 3. = generalized, severe, or incapacitating discomfort |
Other
| Measure | Time frame | Description |
|---|---|---|
| Sore throat | 72 hours after intervention | Measurement on an numeric ten point scale, the patients receive a questionaire |
| Patient Satisfaction | 72 Hours after intervention | Measurement on a numeric ten point scale the patients receive a questionaire |
Countries
Germany
Outcome results
None listed