Respiratory Failure
Conditions
Keywords
Noninvasive Positive Pressure Ventilation, Invasive Positive Pressure Ventilation, tracheotomy
Brief summary
The investigators adopt Noninvasive Positive Pressure Ventilation for weaning in tracheotomy patients innovatively. The investigators randomly allocate the subjects into two groups. One group is weaned by traditional strategy. The other one is weaned by Noninvasive Positive Pressure Ventilation by plugging the tracheotomy tube and deflating the cuff.
Detailed description
The investigators adopt Noninvasive Positive Pressure Ventilation for weaning in tracheotomy patients innovatively .If patients'conditions met our defined criterions, the investigators randomly allocate two groups. One group adopts traditional weaning strategy, the other adopts Noninvasive Positive Pressure Ventilation. If patients' condition deteriorated in group two, the investigators turned them to invasive positive pressure ventilation, until patients adapted in a satisfactory condition, the investigators shift them into Noninvasive Positive Pressure Ventilation. The investigators will extubate the tracheotomy tube, if patients are received Noninvasive Positive Pressure Ventilation more than 24 to 48 hours. After extubation, the investigators try to wean Noninvasive Positive Pressure Ventilation. Successful wean is defined weaning mechanical ventilation more than 48 hours.
Interventions
DEVICENoninvasive ventilation weaning
We adopt Noninvasive Positive Pressure Ventilation in tracheotomy patients by capping the tracheotomy tube and deflating the cuff
Sponsors
Chongqing Medical University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* age ≥ 18 years * tracheotomy mechanical ventilation patients
Exclusion criteria
* pregnancy * respiratory and hemodynamic instability * Recent oral，nasal，facial or cranial trauma or surgery * contra-indications for nasal or facial mask (facial skin lesions,...) * recent history of upper gastro-intestinal surgery * recent history of myocardial infarction * unconscious patients * non cooperative patient
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Main end-point defined as total duration of mechanical ventilation | from admission to hospital to discharge from it or death | The total duration of mechanical ventilation was measured from the patient admitted to hospital to discharge from it or death, an expected average of 2 months. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| duration of extubation tracheotomy tube | from admission to hospital to discharge from it or death | The duration of extubation tracheotomy tube was measured from the patient admitted to hospital to discharge from it or death, an expected average of 2 months. |
| total duration of mechanical ventilation (invasive and non invasive) | from admission to hospital to discharge from it or death | The total duration of mechanical ventilation (invasive and non invasive) was measured from the patient admitted to hospital to discharge from it or death, an expected average of 2 months. |
| duration of invasive mechanical ventilation | from admission to hospital to discharge from it or death | The duration of invasive mechanical ventilation was measured from the patient admitted to hospital to discharge from it or death, an expected average of 2 months. |
| ICU length of stay | from admission to hospital to discharge from it or death | The ICU lentgh of stay was measured from the patient admitted to hospital to discharge from it or death, an expected average of 2 months. |
| hospital length of stay | from admission to hospital to discharge from it or death | The hospital lentgh of stay was measured from the patient admitted to hospital to discharge from it or death, an expected average of 2 months. |
| successful weaning rate | from admission to hospital to discharge from it or death | The sucessful weaning rate was measured from the patient admitted to hospital to discharge from it or death, an expected average of 2 months. |
Countries
China
Outcome results
None listed