Obesity
Conditions
Keywords
Obesity, Healthy Volunteers
Brief summary
This study will test the potential of two techniques using light properties of adipose tissue to diagnose crown-like structures and inflammation to be compared with pathologic examination of adipose tissue biopsies from ongoing clinical studies.
Detailed description
Adipose tissue (fat) inflammation is emerging as an important harbinger of disease development including Type 2 diabetes, heart disease and potentially cancer. The hallmark feature of adipose tissue inflammation is the crown-like structure, a dying fat cell surrounded by immune cells attempting to clear the damage. Current methods for detecting adipose tissue inflammation rely on invasive procedures such as fat biopsies. We propose developing methods that use the light reflection properties of inflamed adipose tissue as a potential non-invasive method to detect adipose tissue inflammation.
Interventions
PROCEDUREFat Biopsy
Fat biopsy
Sponsors
Weill Medical College of Cornell University
Rockefeller University
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
-Subjects currently enrolled in a current Rockefeller University study who will be undergoing adipose tissue biopsies as part of the study protocol
Exclusion criteria
-History of any skin disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Classification of adipose tissue as healthy or inflamed by Raman Spectroscopy | 1 day | Classification of adipose tissue as healthy or inflamed by Raman Spectroscopy |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Steady state oxygenation at the site of tissue biopsy by Diffuse Reflectance Spectroscopy | 1 day | Steady state oxygenation at the site of tissue biopsy by Diffuse Reflectance Spectroscopy |
Countries
United States
Outcome results
None listed