Depression
Conditions
Keywords
Severe Depression, Quality of life, Exercise, BDNF, TBARS
Brief summary
The study aimed to evaluate the use of exercise as a complementary strategy to treat severe major depression in inpatients. Hypothesis: Exercise can be used as a safe and efficacious complimentary strategy in severe depressed inpatients.
Interventions
OTHERExercise
Sponsors
Hospital de Clinicas de Porto Alegre
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* Diagnosis of Major Depressive Disorder according to M.I.N.I (DSM-IV) criteria American Psychiatry Association(1994) * score of 25 or more on Hamilton-17 * not being involved in other physical activity programs during the hospitalization * aged between 18 and 60 years * being able to read, understand, and provide written informed consent
Exclusion criteria
* have three or more cardiovascular risk factors according to Physical Activity Readiness Questionnaire (PAR-Q) * are unable to exercise due other clinical condition * have diagnosis of Schizophrenia, Bipolar disorder or current use of alcohol or other drugs according to M.I.N.I DSM-IV criteria American Psychiatry Association(1994) * if they are taking beta-blocking medications
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Depressive symptoms | 2 weeks of hospitalization (14 days) | Hamilton 17 for depression |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Brain-Derived Neurotrophic Factor(BDNF) | Baseline, after 2 weeks of hospitalization and at discharge (participants will be followed for the duration of hospital stay, an expected average of 3 weeks) | — |
| Quality of Life | Baseline, after 2 weeks of hospitalization and at discharge (participants will be followed for the duration of hospital stay, an expected average of 3 weeks) | WHOQOL-BREF |
| Thiobarbituric acid reactive substances(TBARS) | Baseline, after 2 weeks of hospitalization and at discharge (participants will be followed for the duration of hospital stay, an expected average of 3 weeks) | — |
| Depressive symptoms at discharge (participants will be followed for the duration of hospital stay, an expected average of 3 weeks) | Discharge | Hamilton Scores at discharge |
Countries
Brazil
Outcome results
None listed