Brown Adipose Tissue, Thermogenesis
Conditions
Keywords
Diet-induced thermogenesis, Cold-induced thermogenesis, Brown adipose tissue, Brown fat
Brief summary
Human fat tissue is essentially white fat, the main function of which is to store excess energy intake, and to release it when necessary. Brown fat is far less abundant and is present in the body to burn fat (and thus energy) to generate heat to maintain body temperature around 96 degrees. This phenomenon is called thermogenesis. When humans are exposed to cold on a chronic basis, brown fat expands and becomes more active, and consequently burns more energy. The amount of brown fat is higher during winter, and daily short (20 minutes) exposures to cold might be sufficient to induce its activity. We hypothesized that daily short term (20 minutes) exposure to a cold environment (4 °C) for four weeks increases adaptive BAT-mediated thermogenesis. CIT and DIT will be increased proportionally (the increase in CIT and DIT will be correlated).
Detailed description
This study will have 3 phases: Phase 1: baseline testing. This phase takes place at the beginning of the study to establish several physical, physiological and metabolic studies and includes measures of height, weight, body composition, sedentary and resting metabolic rate in a metabolic chamber as well as your metabolic and cardiac responses to cold. Phase 2: cold exposure (treatment) phase. This phase is initiated immediately after phase 1 and will last 4 weeks. Each work day (Monday to Friday) subjects will have to spend 20 minutes in a cold room wearing light clothes. Phase 3: post-treatment testing. The same physiological and metabolic studies measured at baseline will be repeated over 3 days.
Interventions
OTHERCold Exposure
Participants will spend 20 minutes per day 5 times a week (workdays) in a cold room wearing light clothes (T-shirt, shorts and light shoes) for 4 weeks.
Sponsors
Pennington Biomedical Research Center
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
* Men between the ages of 18-35 years, inclusive * Body mass index (BMI) between 18.5 and 25.0 kg/m2, inclusive, with a stable weight (\<2kg variation) within the past 3-6 months * Non smokers * On no medication or recreational drugs * Healthy as assessed by a standard self-reported screening health questionnaire * Provide written informed consent
Exclusion criteria
* Smokers * Individuals taking any medications * Individuals taking any stimulants * Individuals taking beta-blockers * Individuals with diabetes or impaired fasting glucose as defined by theADA criteria, i.e. fasting plasma glucose concentration ≥ 5.6 mmol/L (100 mg/dl). * Individuals with chronic alcohol consumption (\> 3 drinks per day) or drug abuse * Individuals unable to abstain from caffeinated beverage or alcohol the days of study * Individuals with pacemakers or defibrillators * Individuals with history of heart disease or history of stroke * Individuals having a significant recent loss or gain of weight * Individuals involved in regular (\> 3 times per week), intense competitive sporting activities. * Individuals involved in intensive exercise activity.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Energy Expenditure | After 4 weeks of cold exposure | Change in energy expenditure is measured within 24 hours (acute) and after 4 weeks (chronic) of cold exposure with either bed-side calorimeter or whole-room calorimeter. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Temperature | After 4 weeks of cold exposure | Change in temperature acute (within 24 hours) and chronic (after 4 weeks) temperature from baseline as measured by either capsule (core body temperature) or infrared imaging (surface temperature). |
Countries
United States
Outcome results
None listed