The Efficacy of Periarticular Single Drug Compared With Multimodal Drug Injection in Controlling Pain After TKA

A Comparative Study on the Efficacy of Periarticular Single Anesthetic Drug Compared With Multimodal Drug Injection in Controlling Pain After Total Knee Arthroplasty: A Double Blinded Randomized Controlled Trial

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01898052

Acronym

TKA

Enrollment

Registered

2013-07-12

Start date

2012-10-31

Completion date

2014-03-31

Last updated

2014-04-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative Pain

Keywords

pain control, periarticular injection, Total knee arthroplasty, levobupivacaine, multimodal drug injection

Brief summary

The purpose of this study is to determine the periarticular multimodal drug injection has more efficacy for controlling pain after TKA than single anaesthetic drug injection.

Detailed description

Many studies have to determine the efficacy of periarticular multimodal drug injection or single local anaesthetic drug comparing with placebo for pain controlled in TKA. But in this study would like to determine which one of both drugs are more efficacy. In multimodal drug injection consist of levobupivacaine, morphine, ketorolac and epinephrine while single anaesthetic drug has levobupivacaine and epinephrine.

Interventions

DRUGsingle anaesthetic drug

inject periarticular tissue of the knee after implantation

DRUGmultimodal drug injection

inject periarticular tissue of the knee

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

50 Years to 85 Years

Healthy volunteers

Inclusion criteria

* primary osteoarthritis of the knee who undergoing unilateral primary total knee arthroplasty * age 50-85 years old

Exclusion criteria

* unable to perform spinal anaesthesia * history of drug allergies; local anaesthesia, Non-steroidal anti-inflammatory drugs, morphine, epinephrine * cognitive function impairment * renal impairment (creatinine clearance \< 30 mL/min) * liver impairment, gastrointestinal bleeding

Design outcomes

Primary

Measure	Time frame	Description
pain score	48 hour after surgery	pain score at rest and activity between 2 groups every 4 hours until 48 hours after surgery

Secondary

Measure	Time frame	Description
time to request analgesic drug	48 hours	time when patient request morphine from patient controlled analgesia after intra-operative drug injection

Other

Measure	Time frame	Description
drug consumption	48 hours	morphine consumption that record from patient controlled analgesia
knee score	3 months	Knee injury and osteoarthritis outcome score (KOOS) at pre-operation and post-operation 3 months

Countries

Thailand

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026