Myocardial Oedema, ST Segment Elevation Myocardial Infarction
Conditions
Keywords
STEMI, Myocardial edema, Cardiovascular magnetic resonance
Brief summary
Cardiac magnetic resonance imaging (CMR) is a non invasive technique used to obtain functional and anatomical information on the heart. Several CMR parameters measured after primary percutaneous coronary intervention (PPCI) have been shown to have prognostic value and are increasingly being used as surrogate endpoints in clinical trials. Myocardial oedema is a prognostic indicator following myocardial infarction1. Myocardial salvage is calculated as the myocardial oedema minus infarct size; this again is a prognostic indicator following STEMI. However, myocardial oedema imaging is controversial. There are multiple sequences available, with no standardisation of sequences used to assess this surrogate endpoint. The investigators propose to conduct a study to measure the myocardial oedema by all available techniques to determine the agreement between these methods.
Interventions
OTHERCardiac magnetic resonance imaging
Sponsors
Elisa McAlindon
Study design
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* STEMI * providing written informed consent
Exclusion criteria
* contraindication to CMR, * atrial fibrillation, * claustrophobia, * eGFR \< 30
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The mass of myocardial oedema measured by CMR | Day 2 following STEMI |
Secondary
| Measure | Time frame |
|---|---|
| Extra cellular volume | Day 2 following STEMI |
Countries
United Kingdom
Outcome results
None listed