Female Infertility Due to Diminished Ovarian Reserve
Conditions
Keywords
Poor Ovarian Response, Poor Responders, IVF/ICSI, Growth Hormone
Brief summary
in this study, we are trying to monitor the effect of the addition of growth hormone on the different down regulation protocols ( long, short, antagonist and microflare). The outcome will be primarily assessed by the clinical pregnancy rates.
Detailed description
Poor responders undergoing IVF/ICSI cycles have emerged as a major problem. the need to find a proper stimulation protocol is a must. in this study we are trying to detect the best stimulation protocol ,in addition to growth hormone ,that can give the highest pregnancy rates in these patients.
Interventions
Sponsors
Woman's Health University Hospital, Egypt
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
ESHRE consensus 2011,At least two of the following three features must be present: * Advanced maternal age (≥40 years) or any other risk factor for POR; * A previous POR (≤3 oocytes with a conventional stimulation protocol); * An abnormal ovarian reserve test (i.e. AFC \< 5-7 follicles or AMH \< 0.5 -1.1 ng/ml).
Exclusion criteria
* female patients with causes of infertility other than poor ovarian reserve * females suffering from congenital or acquired uterine anomalies * females with focal uterine lesions * females who had previous ovarian surgeries * females with history of previous exposure to radiotherapy , or chemotherapy * females refusing to get enrolled in the study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Numbers of oocytes retrieved and number of fertilized oocytes | 2 years | Number of oocytes retrieved on the day of vaginal egg collection guided by trans vaginal ultrasound scan , 35 hours after hCG administration. |
Countries
Egypt
Outcome results
None listed