Aura, Headache, Migraine
Conditions
Keywords
Headache, Migraine, Aura, Cerebral hemodynamics
Brief summary
In this study the investigators will investigate the following hypothesis * that hypoxia induce migraine headache and migraine aura * the aura phase is associated with a spreading reduction in cerebral blood flow * the migraine headache is associated with dilatation of intra- and extracerebral arteries * the migraine headache is associated with changes in brain metabolism * the pre-ictal stage of a migraine attack with aura is associated with specific patterns in neural activity.
Detailed description
To investigate migraine with aura symptoms during and after hypoxia. With magnetic resonance imaging the investigators will investigate changes in * regional cerebral blood flow (rCBF) * resting state functional connectivity * circumference of the middle cerebral artery(MCA), internal carotic artery, superficial temporal artery, medial meningeal artery, external carotic artery * brain metabolism And compare these changes with a aged match healthy control group.
Interventions
OTHERHypoxia
Inhalation of hypoxic air (8-12% oxygen content)
OTHERPlacebo
Inhalation of atmospheric air
Sponsors
Danish Headache Center
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
Migraine with aura patients and Helthy volunteers as controls: * Aged 18-40 * 50-100 kg
Exclusion criteria
* Tension type headache more than 5 days/month * Other primary headaches * Daily medication except contraceptives * Drug taken within 4 times the halflife for the specific drug except contraceptives * Pregnant or lactating women * Headache or migraine attack within the last 48 hours before start of trial * Hypertension * Hypotension * Respiratory or cardiac disease * smoking Extra
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Headache and aura | 24 h | Comparison between hypoxia and placebo (atmospheric air) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| artery circumference | Baseline, 120 and 200 min | Hypoxia induced changes in intra- and extracranial circumference |
| Cerebral blood flow | Baseline, 120 and 200 min | Hypoxia induced changes in cerebral blood flow |
| BOLD response in visual cortex | Baseline, 170 min and 220 min | Hypoxia induced changes in BOLD response |
| Brain metabolism | Baseline, 180 min and 230 min post hypoxia | Hypoxia induced changes in brain metabolism |
Countries
Denmark
Outcome results
None listed