Male Infertility
Conditions
Keywords
male infertility,oligo spermia
Brief summary
The purpose of this study is to determine whether the effect of mixed herbals drug (citrus, citrolus vol, lan, carrot seed, zingiber, onion, basil, cinnamon) administration on male infertility: oligospermia
Detailed description
In the last few years, a marked decrease in the quality of semen has been reported. Infertility is one of the major health problems in 10 to 15% of couples' lives; from which approximately 50% of couple's infertility is due to Male factors. The aim of the present study was to evaluate an herbal mixed effects on spermatogenesis and the normal production of sperm. Researchers have reported that using antioxidants and vitamins A, B, C, E, flavonoids, Sulfur compounds, terpenoids and phenolic compounds in the daily diet can protect sperm. In this study the investigators aimed to assess synergistic effect of these herbal compounds in male Infertility. 700 mg tablet for 180 consequence days/daily will be advising, for 40 patients semen samples in 1th and 180 day after treatment will take, in andrology lab according WHO method:samples put into 2 mL of medium (Hams F10) containing 0.5% bovine serum albumin. After 5 min incubation at 37oC (with 5% CO), the sperm samples were determined using the standard haemocytometric method, and sperm motility was analyzed by microscope (Olympus IX70) at 10 field and reported as the mean of motile sperm according to WHO methods . The sperm abnormality was evaluated according to the standard method of Narayana .Briefly, smears of the sperm suspension were made on clean glass slides and stained with periodic acid-Schiff's reaction haematoxylin. The stained smears were observed under a light microscopic with 40× magnification. The sperms were classified into normal and abnormal. The total sperm abnormality was expressed as percentage incidence. Other biochemical tests will be doing according the our research protocol and thesis for blood samples for measure LH, Testosterone, TAC, Glc and Cholesterol.
Interventions
DIETARY_SUPPLEMENTcoated tablet
this supplement contains 700 mg of 8 natural herbals: Citrus & ZINGIBER OFFICINALE & Onion & Ocimum basilicum & Cinnamomum zelanicum & Citrullus lanatus & Citrullus vulgaris & Daucus carota
Sponsors
Islamic Azad University of Tabriz
Tabriz University
Arash Khaki
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
SUPPORTIVE_CARE
Masking
SINGLE (Caregiver)
Eligibility
Sex/Gender
MALE
Age
25 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* all patients suffering from oligospermia are included
Exclusion criteria
* any diseases
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Sperm count variation | First day of research, 2th time for sampling is 180 days after treatment | Semen analysis according WHO methods |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Sperm motility | 1th time in first day of research, 2th time after 180 days of treatment | Semen analysis |
| Sperm Viability | 1th time in first day of research, 2th time after 180 days of treatment | Semen analysis |
Other
| Measure | Time frame | Description |
|---|---|---|
| Testosterone levels | 1th time in first day of research, 2th time after 180 days of treatment | Testosterone analysis |
| Serum Total antioxidant levels | 1th time in first day of research, 2th time after 180 days of treatment | Total antioxidant measurement in serum |
Countries
Iran
Outcome results
None listed