Contrast Agent, Endothelial Function, Cytokines, Apoptosis of Endothelial Progenitor Cell, Free Radical, Alpha-lipoic Acid
Conditions
Keywords
Contrast agent, endothelium, Free radical, Alpha lipoic acid
Brief summary
Contrast medium is essential for diagnosis of many diseases. However, recent studies showed that contrast agents can induce renal injury and is associated with poor long-term clinical outcome, especially in diabetes. To date, no data are available on the relationship between contrast medium and endothelial function. Endothelial dysfunction is known to precede atherosclerosis and is considered a risk marker for future development of cardiovascular disease. Therefore, we hypothesized that contrast agents may induce endothelial dysfunction in healthy men. In addition, we hypothesized that contrast induced endothelial dysfunction via free radicals. Thus, we also test alpha-lipoic acid whether or not protect endothelial dysfunction induced by contrast agents.
Interventions
OTHERContrast agent
Sponsors
Xiang Guang-da
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
HEALTH_SERVICES_RESEARCH
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
MALE
Age
20 Years to 30 Years
Healthy volunteers
Yes
Inclusion criteria
* healthy men * 20 yr \< = age \< = 30 yr * 20 \< = body mass index \< = 25
Exclusion criteria
* age \< 20 yr or \> 30 yr * dysfunction for liver, renal, and heart. * other diseases such as diabetes, hypertension, thyroid disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The endothelial dysfunction and the protective role of alpha-lipoic acid | 6 months |
Secondary
| Measure | Time frame |
|---|---|
| The apoptosis of endothelial progenitor cell | 6 months |
Countries
China
Outcome results
None listed