Assessment of Renal Function in Cirrhotic Patients

Assessment of Renal Function in Cirrhotic Patients -A Comparison of Cystatin C and Creatinine Based Calculations to 125I-iothalamate

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01895114

Enrollment

213

Registered

2013-07-10

Start date

2010-12-31

Completion date

2025-01-13

Last updated

2025-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Liver Failure, Renal Failure

Keywords

Renal function, cirrhotic patients, transplant evaluation

Brief summary

The purpose of this study is to help determine whether cystatin C is a more sensitive laboratory measurement for renal function in cirrhotic patients.

Detailed description

Serum cystatin C, creatinine clearance based calculations, and 125I-Iothalamate clearance (Glofil) will be obtained in 220 patients with cirrhosis. Utilizing this information, the correlation between cystatin C and 125I-Iothalamate clearance will be obtained. In addition, the current serum creatinine based calculations and true creatinine clearance will also be correlated with 125I-Iothalamate clearance. The results of this study should help to determine whether serum cystatin C is a more sensitive laboratory measurement of renal function in patients with cirrhosis.

Interventions

None listed

Study design

Observational model

OTHER

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* over 18 undergoing evaluation for a liver transplant

Exclusion criteria

* known allergy or sensitivity to 125I-Iothalamate

Design outcomes

Primary

Measure	Time frame
Creatinine based blood and urine laboratory tests as a measure of renal function in patients with chirrosis of the liver.	24 hours

Countries

United States

Outcome results