Nausea, Vomiting, Metastatic Liver Cancer
Conditions
Keywords
prevention and treatment, improvement of the patient's appetite, TACE
Brief summary
Observation on acupoint electric stimulation combined with tropisetron in preventing and treating nausea and vomiting and improving the patient's appetite after TACE for primary or metastatic liver cancer patients.
Detailed description
* Classification of nausea and vomiting, as measured by NCI CTC-AE version 3 * The improvement of appetite, as measure by the classification of Appetite in accordance with NCI CTC-AE version 3. * Quality of life: use M. D. Anderson symptom scale (the m. d. Anderson Symptom Inventory,MDASI)
Interventions
DEVICEacupoint electric stimulation
acupoint electric stimulation combined with tropisetron 6mg before TACE
DRUGtropisetron
only tropisetron 6mg before TACE
Sponsors
Fudan University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* ECOG physical status 0,1,2 * would accept the transcatheter hepatic arterial chemoembolization of primary or metastatic liver cancer patients; * Adult male and female 3, age 18 years old; * the chem-scheme of arterial infusion chemotherapy based on oxaliplatin dosage of 200mg; * signed the informed consent and understand the study design; * Organ function examination in patients must meet the following laboratory indexes: Neutrophil\>500/Ul, hemoglobin \> 8 gm/dL, platelet \>100000/uL,Creatinine \< 2 mg/dL bilirubin \< 1.5 mg/dL, , alanine aminotransferase \< 3 times the normal value, albumin \>30g/L * understand and complete quality of life scale ; * women of childbearing age urine pregnancy test was negative.
Exclusion criteria
* The combined use of other venous chemotherapy within 5 days after TACE; * skin infection on or near the points; * skin hyperalgesia, unable to withstand electrical stimulation; * other confounding factors may cause nausea and vomiting (such as intestinal obstruction, anorexia, etc.); * heart, cerebrovascular accident history or the history of spinal cord injury; * intestinal obstruction lead to nausea and vomiting * installing pacemaker; * cognitive dysfunction, unable to finish Scale; * currently using acupuncture therapy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Classification of nausea and vomiting | 12 month |
Secondary
| Measure | Time frame |
|---|---|
| The improvement of appetite | 12 month |
Countries
China
Outcome results
None listed