Obesity, Overweight
Conditions
Brief summary
The investigators have previously shown the intact protein from cod filet improves glucose regulation and serum lipid profile in overweight adults. A large amount of trimmings from various fish species such as cod is thrown away or sold at very low prices for animal feed, and analyses of the amino acid composition reveals that this can be a good protein source for humans. Two fractions are normally isolated from intact fish meal, i.e. water soluble and non-water soluble proteins. In the present study the investigators will compare these fractions, by studying their effects on glucose regulation in overweight/obese adults.
Detailed description
Participants receive 6g per day of water soluble on non-water soluble cod protein as tablets for 8 weeks.
Interventions
DIETARY_SUPPLEMENTCod protein from presscake
6g protein per day for 8wk
DIETARY_SUPPLEMENTCod protein from presscake + stickwater
6 g protein per day for 8 wk
DIETARY_SUPPLEMENTControl
Sponsors
Granit AS Transport & Tourism
Norwegian Seafood Center
Nofima
University of Bergen
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
20 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* BMI\>28 * healthy * fasting blood glucose \<7.0 mmol/L * stable body weight with less than 5 kg fluctuation during the last 4 months
Exclusion criteria
* known disease or metabolic disturbances related to overweight or obesity * use of prescription medications that affect blood glucose, blood lipids or inflammatory status * allergies towards fish or seafood * undertaking a weight loss diet * tobacco use exceeding \>15 cigarettes/day * pregnancy or breastfeeding * high seafood consumption * use of dietary supplements including cod liver oil or other marine fatty acids * allergies towards fish, milk, egg
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Glucose tolerance | 8 weeks | Serum glucose will be measured in fasting and postprandial state |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Gene expression | 8 weeks | Changes in gene expression in adipose tissue related to the circulating markers of glucose regulation. |
| Amino acids and amino acid metabolites | 8 weeks | Amino acids and amino acid metabolites will be measured in serum and urine |
| Comparisons of metabolites and co-factors involved in one-carbon metabolism in serum and urine | 8 weeks | Concentrations of relevant metabolites and co-factors were measured in serum and urine |
Countries
Norway
Outcome results
None listed