Dehydration
Conditions
Keywords
dehydration, fluid balance, exercise, heat, body weight, performance
Brief summary
The purpose of the APEX study is to determine whether carbohydrate-electrolyte beverage intake promotes fluid balance during exercise in the heat compared with water or placebo intake.
Detailed description
Exercise in the heat has large effects on cardiovascular strain, the ability to regulate core body temperature, and performance because of an increase in the reliance on body fluid distribution to the skin to maintain adequate sweat rates and heat dissipation. Carbohydrate-electrolyte beverage intake during exercise in the heat may improve fluid balance and subsequent physical performance. The participants will be assigned each arm in a randomized, counterbalanced, cross-over fashion separated by at least 2 weeks. Participants will be placed in a heated environment for the duration of the exercise intervention.
Interventions
OTHERExercise Intervention
Exercise intervention trials will consist of a steady-state bout of exercise at \ 70% VO2peak and a timed performance test on a cycle ergometer in a heated environment.
Sponsors
Pennington Biomedical Research Center
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
MALE
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
* Males aged 18-35 years * Healthy (No uncontrolled disease)
Exclusion criteria
* No medications that influence fluid balance * No uncontrolled disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Fluid Balance | 120 minutes | Fluid balance will be determined by change in body weight during the 120 minutes steady-state exercise bout in the heat. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Rate of fluid uptake in the GI tract | 30 minutes | Fluid uptake in the GI tract be assessed by D20 accumulation in the plasma. |
| Amount of carbohydrate oxidized | 120 minutes | Carbohydrate oxidation rates will be assessed by indirect calorimetry. |
| Cardiovascular responses | 120 minutes | Heart rate and blood pressure will be assessed during exercise. |
| Thermoregulatory responses | 120 minutes | Body temperatures will be assessed during exercise. |
| Physical Performance | 30 minutes | Performance during the timed exercise trial will be improved with carbohydrate-electrolyte beverage intake compared with water and placebo intake. |
Countries
United States
Outcome results
None listed