Suicide
Conditions
Keywords
suicide, ketamine, low-dose ketamine, suicidal ideations, emergency department
Brief summary
This study will enroll patients presenting to the emergency department with acute suicidal ideation meeting inclusion and exclusion criteria. Patients will be randomized to one of three arms: ketamine (intervention) or diphenhydramine (control) or placebo (control). Serial measurements will be made in the ED and at follow-up intervals.
Interventions
DRUGKetamine
Sponsors
Brooke Army Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
* Patients age 18 to less than 75 who present to the SAMMC ED with either overt or incidental suicidal ideations with a SADPERSONS score 5 or greater that the treating provider feels warrant formal evaluation.
Exclusion criteria
* -Poor vital sign stability hypoxia: O2 \< 95%, hypotension: SBP\< 90 hypertension: SBP\>180 Heart rate: \< 50 or \>120 Respiratory Rate: \<10 or \>30 * Altered mental status or intoxication * Patient is unwilling to participate or provide informed consent * Any allergy to ketamine or diphenhydramine * Patient is female of child-bearing age and unwilling to provide urine or blood for HCG analysis * Pregnancy or breast feeding * Presence of chronic oxygen-dependent pulmonary disease, liver cirrhosis, or renal disease requiring dialysis * Presence of ischemic heart disease, heart failure, or a history of unstable dysrhythmias * Presence of intracranial mass or vascular lesion. * Presence of a history of psychosis or hallucinations (as assessed by electronic chart review) * Weight greater than 115 kg or less than 45kg * History of increased intracranial pressure/hypertensive hydrocephalus * Non-English speaking patients * Patient is acutely psychotic * Provider feels that patient currently or likely will require chemical and/or physical restraints * History of prolonged QT-interval
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in Beck Scale for Suicidal Ideation | 2 hours |
Countries
United States
Contacts
Primary ContactSteven G Schauer, DO
Backup ContactShawn M Varney, DO
Outcome results
None listed